simstudy: Illuminating research methods through data generation

Illuminating Atherogenesis Through Mathematical Modeling

Privacy Preservation through Data Generation

Many databases will or can not be disclosed without strong guarantees that no sensitive information can be extracted. To address this concern several data perturbation techniques have been proposed. However, it has been shown that either sensitive information can still be extracted from the perturbed data with little prior knowledge, or that many patterns are lost. In this paper we show that ge...

Illuminating human health through cell mechanics.

Cells reside in mechanically rich and dynamic microenvironments, and the complex interplay between mechanics and biology is widely acknowledged. Recent research has yielded insights linking the mechanobiology of cells, human physiology, and pathophysiology. In particular, we have learned of the cell's astounding ability to sense and respond to its mechanical microenvironment. This seemingly inn...

Illuminating Mental Representations through Speech and Gesture

Can the gestures people produce when describing algebra word problems offer insight into their mental representations of the problems? Twenty adults were asked to describe six word problems about constant change, and then to talk aloud as they solved the problems. Two problems depicted continuous change, two depicted discrete change, and two depicted change that could be construed as either con...

Illuminating the Transcriptome through the Genome

Sequencing the human genome was a huge milestone in genetic research that revealed almost the total DNA sequence required to create a human being. However, in order to function, the DNA genome needs to be expressed as an RNA transcriptome. This article reviews how knowledge of genome sequence information has led to fundamental discoveries in how the transcriptome is processed, with a focus on n...